A research team from NIT Rourkela has created a bioink for 3D bioprinting of bone-like structures. Led by Prof. Devendra Verma, the team developed a composition of chitosan, gelatin, and nanohydroxyapatite that mimics natural bone properties. The research has been published in the Journal of Biomaterials Science and Carbohydrate Polymers, with a patent (No. 562791) granted in March 2025.
The bioink addresses limitations in traditional bone repair methods like grafting and metal implants. Unlike conventional bioinks that require extended lab preparation, this formulation remains liquid at room temperature and transforms into a gel when exposed to body temperature and pH. This property allows direct application to injury sites without separate printing and implantation procedures.
“This research contributes to the growing field of 3D bioprinting by offering a bioink that is entirely natural, easy to apply, and capable of supporting bone regeneration,” said Prof. Verma. The bioink contains specialized nanofibers that enhance cell attachment and proliferation during the healing process.
The Department of Health Research, Government of India, has provided funding for this project. The bioink shows potential for treating large bone defects from accidents, infections, or surgeries, with particular relevance for reconstructive surgeries of the skull and face where precise bone repair is needed.
The research team, which includes scholars Tanmay Bharadwaj and Shreya Chrungoo, plans to test the bioink in animal models. They aim to develop a scalable production process in a Good Manufacturing Practices facility for future clinical trials. To support commercialization efforts, the researchers have established a startup called Quixotix Bioprinting.
Source: expresshealthcare.in