3D Printing
News Contact us Seen on social
Home / News / Using AI and AM for Organoid Production

Using AI and AM for Organoid Production

October 15, 2022

Living organs for medical experimentation are pretty hard to come by, on account of human beings actually using them on a day to day basis. To rectify this, the concept of the organoid has been developed.

Functional Organ Models

Organoids are mini-versions of organs that replicate various biological functions, and they are grown in-vitro, in a petri dish or test tube or some other kind of container outside of the normal environment of the body.

Manufacturing of organoids has had its limitations however, as it has been difficult to demonstrate consistent and robust extraction of mature organoids from renewable cells.

This could be about to change though, thanks to a team of researchers from the Swanson School of Engineering at the University of Pittsburgh who have been awarded funding to further research into organoid production using AI and 3D printing.

organoids
In-vitro organoids. (Image credit: University of Pittsburgh)

The team of researchers, led by principal investigator Ipsita Banerjee, have been awarded $500,000 by the National Science Foundation to utilize artificial intelligence to accelerate the development of organoids, which has traditionally been heavily based on a trial-and-error approach. The team is multi-disciplinary and comes from various institutes at the University of Pittsburgh, the Allegheny Health Network, and Duquesne University.

New Method

Usually, organoids are created using a chemistry-based experimental approach, but the new method involves mechano-transduction pathways, or the process in which cells respond to mechanical stimuli, to regulate manufacturing while also exploiting cytoskeletal rearrangements that are part of the organoid phenotype.

For those who do not have a background in cellular biology, mechano-transduction is any of various mechanisms by which cells convert mechanical stimulus into electrochemical activity.

In this case, the mechano-transduction will be controlled by bioprinting the organoid phenotype, while machine learning models will identify signature cytoskeletal states associated with the phenotype. The AI will assist with accelerating development and will enhance accuracy in predictions of organoid behavior for further research.

“Our vision is to enable organoid technology to finally realize its potential in clinical research and drug development,” said Banerjee.

“This breakthrough research will benefit society and the healthcare system at large by creating a more efficient, effective and sustainable way to design these structures.”

organoid
Non-printed intestinal organoid. (Image credit: Meritxell Huch, PLOS Biology journal) By Meritxell Huch

The printed organoids will be used to conduct complex research on human tissue physiology, genetic diseases, organ-specific infectious diseases and cancer.

Organoids can be used for replicating functions of almost any organ, be it via the production of lung, mammary, liver, stomach, pancreas, and even cerebral organoids.

“Central to our goal of organoid manufacturing is the integration of bioprinting and artificial intelligence to enable automated and non-invasive learning of different types of organoids,” said Banerjee.

“Bioprinting also will enable us to scale up the production of these structures in quantity and quality over time, without the restrictions we currently face using traditional methods.”

The research will provide trainees with multidisciplinary skill sets, encompassing bioprinting, organoid engineering, imaging, and AI methods. The funding has been awarded as part of the National Science Foundation’s Future Manufacturing program.

nasa vascular challenge
Related Story
Two Teams Win NASA’s Vascular Tissue Challenge Using 3D Printing
Share:
WhatsApp Twitter Facebook LinkedIn Buffer Reddit E-mail
About the author | Phillip Keane
Phillip is an aerospace engineer from UK. He is a graduate of Coventry University (UK), International Space University (France) and Nanyang Technological University (Singapore), where he studied Advanced Manufacturing at the Singapore Centre for 3D Printing.
Latest posts

3D Printed Switchable Explosives Offer Safer Solutions for Mining and Military Applications

Researchers at the Los Alamos National Laboratory have developed "switchable" high explosives that require an inert fluid, like water, to be activated, minimizing... read more »

Military
Experimental setup and detonation time lapse

Engineer Wins Prize for 3D-Admix Concrete Printing Additive

Fort Bragg resident and civil engineer, Michael Butler, has won the Most Innovative Product Award at the 2023 World of Concrete International Exhibition.... read more »

Construction
concrete and 3D-Admix

Patent Granted for 3D Printing Embossing Technology

Northann Corp has obtained a European patent for its innovative "DSE Embossing Technology." This new method combines positive and negative embossing techniques in... read more »

News
DSE embossed example

USAF Global Strike Command Embraces 3D Printing for Future Weapon Sustainment

The Air Force Global Strike Command (AFGSC) is turning to 3D printing to address its weapon sustainment needs. As the field of additive... read more »

Military
USAF mechanical engineer

Particle Accelerator Sheds New Light on Solidification of Metals During 3D Printing

Researchers at the National Institute of Standards and Technology (NIST), KTH Royal Institute of Technology in Sweden, and other institutions have made a... read more »

3D Printing Metal
Shooting X-rays

CyBe to 3D Print Florida’s First Villa

Dutch construction printing company CyBe Construction is set to print their first 3D concrete villa in Florida, utilizing mobile printing technology to construct... read more »

Construction
CyBe Render

Custom 3D Printed Gaming Mouse Now on Kickstarter

Canadian start-up Formify has launched a Kickstarter campaign for their custom 3D printed gaming mouse, designed to enhance player performance in Esports. Already... read more »

News
custom 3d printed gaming mouse

3D Printed Titanium Cranks Now Available for Electric Mountain Bikes

Cane Creek is taking electric mountain bikes to the next level with the introduction of their 3D printed titanium Electric Wings crankset. Designed... read more »

3D Printing Metal
Swanky and robust

New Technique Produces Ultra-Lightweight, Waste-Free Concrete Structures

Researchers at the University of Michigan's Taubman College have developed an innovative 3D printing method that creates ultra-lightweight, waste-free concrete structures. The "Shell... read more »

Construction
Tubular

Social

  • Facebook Facebook 3D Printing
  • Linkedin Linkedin 3D Printing
  • Twitter Twitter 3D Printing
  • Modix BIG-60 Modix BIG-60
    600 x 600 x 660 mm
    $4,900
    Buy Now
  • Geeetech THUNDER Geeetech THUNDER
    250 x 250 x 260 mm
    $489
    Buy Now
  • Geeetech ALKAID Geeetech ALKAID
    82 x 130 x 190 mm
    $99
    Buy Now
  • Geeetech Mizar M Geeetech Mizar M
    255 x 255 x 260 mm
    $399
    Buy Now
  • Geeetech Mizar S Geeetech Mizar S
    255 x 255 x 260 mm
    $279
    Buy Now
  • Fusion3 F410 Fusion3 F410
    355 x 355 x 315 mm
    $4,599
    Buy Now
  • Geeetech A30T Geeetech A30T
    320 x 320 x 420 mm
    $449
    Buy Now
  • Hands-On Review: The Mole 3D Scanner
    Hands-On Review: The Mole 3D Scanner Learn More
  • Hands-On Review: Creality Ender 5 S1
    Hands-On Review: Creality Ender 5 S1 Learn More

Featured Industries

  • Automotive
  • Aerospace
  • Construction
  • Dental
  • Environmental
  • Electronics
  • Fashion
  • Medical
  • Military
  • Industry MAGNUM Industry MAGNUM
    1500 x 1200 x 1200 mm
    €159.000
    Request a Quote
  • Modix BIG Meter Modix BIG Meter
    1010 x 1010 x 1010 mm
    from $13,500
    Request a Quote
  • Modix BIG-120Z Modix BIG-120Z
    600 x 600 x 1200 mm
    from $7,500
    Request a Quote
Join our newsletter

Our newsletter is free & you can unsubscribe any time.

Company Information

  • What is 3D Printing?
  • Contact us
  • Join our mailing list
  • Advertise with us
  • Media Kit
  • Nederland 3D Printing

Blog

  • Latest News
  • Use Cases
  • Reviews
  • 3D Printers
  • 3D Printing Metal

Featured Companies

  • Modix
  • Industry
  • Geeetech

Featured Industries

  • Automotive
  • Aerospace
  • Construction
  • Dental
  • Environmental
  • Electronics
  • Medical
  • Military
  • Fashion
  • Art
2023 — Strikwerda en Dehue
  • Home
  • Join our mailing list
  • Contact us
Featured Industries
  • Automotive
  • Aerospace
  • Construction
  • Dental
  • Environmental
  • Electronics
  • Medical
  • Military
  • Fashion
  • Art
Blog
  • Latest News
  • Use Cases
  • Reviews
  • 3D Printers
  • 3D Printing Metal
Company Information
  • What is 3D Printing?
  • Contact us
  • Join our mailing list
  • Advertise with us
  • Media Kit
  • Nederland 3D Printing
We serve cookies on this site to analyze traffic, remember your preferences, and optimize your experience.
Details
Close